Thursday, September 8, 2022

The Differences between Hiking and Trekking

A Yale University PhD graduate, Dr. Thomas “Tom” Brutnell is a scientist with over 25 years of experience in plant molecular biology, genetics, and genomics. He currently serves as a vice president at Gateway Biotechnology, a drug development company in St. Louis, Missouri. He also serves as a visiting scientist at the Chinese Academy of Agricultural Sciences in Beijing, China. In his free time, Thomas Brutnell is an avid walker and occasional runner.

Given the extensive amount of time many of us now spend behind a computer screen, it is important to incorporate some daily standing, stretching and walking breaks into the daily work schedule. This is particularly relevant to those of us who now work from home and spend even less time walking to and from our cars into the office in the morning or routinely skip heading out to lunch for a break. Incorporating a short 10 to 15 min walk between a morning and afternoon meeting is a great way to rest your eyes, wrists and fingers from the screen and keyboard. It is also important to be intentional in standing at least every hour. Just one or two minutes of standing and walking around the living room every hour can actually benefit your metabolism and provided a break for your eyes.

In addition to taking short breaks during the day, incorporating 20 min or more of strenuous exercise two or three times a week is not only good for the body but good for the mind. A 20 min run through the woods or even on a treadmill will do more to help relieve stress if you don’t think about work and instead focus on your breathing, your posture or on the rhythm of your pace. The time spent on these activities will more than make up in productivity (and longevity!) for time lost behind the screen.



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Monday, January 20, 2020

The Significant Risks of Hearing Loss Among Musicians

woman standing watching LED light musical instrument
Photo by Spencer Imbrock on Unsplash

Thomas Brutnell
is an established presence in the Missouri entrepreneurial community who consults in the agricultural biotechnology sphere and serves as the vice president of Gateway Biotechnology, Inc. With the latter firm, Thomas Brutnell is focused on combating hearing disorders through innovative, plant-based therapeutics.


One major hearing loss issue is caused by exposure to loud sounds over an extended period of time. This is particularly prevalent among those in the music business; musicians including Neil Young and Coldplay’s Chris Martin have reported developing tinnitus over the course of their careers.

As reported in an AARP article, a German study examining 7 million health insurance records from 2004 to 2008 found that musicians were four times more likely to experience noise-induced hearing loss than workers in any other profession.

The reason for this has to do with sheer volume, since musicians are subject to longer exposure of sounds over 85 decibels, a noise level that is similar to what one would experience with busy street traffic. Anything over 85 decibels is considered risky, while the pain threshold is at 125 decibels. Average music concerts are 115 decibels, or slightly below the sound of an ambulance or jackhammer. In some arenas, sound can reach 140 decibels, which exceeds levels associated with a jet engine.

Unfortunately, it does not take long for the negative effects to accumulate for musicians. 3M Occupational Health and Environmental Safety Division data points to damage occurring after only three minutes of exposure to sound at the 115 decibel level.

Friday, December 27, 2019

Teaching An Old Gut Microbe A New Trick

Wednesday, October 9, 2019

A Brief History of Plant Use in Medicine

Plant
Photo by vickholius nugroho on Unsplash

Thomas Brutnell, PhD, is co-founder of the agricultural biotech company Benson Hill Biosystems and consults with various major seed companies. Passionate about the use of plants in medicine, Thomas Brutnell is the vice president of Gateway Biotechnology, a company that is developing hearing loss treatments using natural, plant products.

Plants have been a rich source of remedies for humans for millennia. Evidence exists proving that ancient civilizations used plant-based products to treat diseases. The oldest record of medicinal plant usage dates back approximately 5,000 years and is a collection of about a dozen drug preparation recipes written on Sumerian clay tablets. Other records, dating back 2,600 years, are attributed to the Mesopotamians and were also written on clay tablets.

Ancient Chinese, Babylonian, Assyrian, and Egyptian civilizations also had long histories of using herbs as medicine. This knowledge was inscribed in cuneiform on clay tablets and passed from generation to generation. The Egyptians recorded their medicinal recipes on tombs and on papyrus. The Ebers Papyrus, for example, is one of the oldest of these recordings. It contains more than 600 plant-based prescription drugs and was studied by, among others, Greek medical writer Hippocrates, considered by many as the father of medicine.

Through his writings, which included more than 200 medicinal plants, Hippocrates paved the way for other European medics like Celsus (25BC – 50AD) and Dioscorides who penned the famous De Matteria Medica in 77 AD. The book contained more than 900 drugs, most of which were based from plants. The book was translated into several languages and its prescriptions used for over a millennium. Along the way, more medicinal plants were discovered and written about by European and American medical researchers.

Wednesday, August 14, 2019

Gateway Biotechnology Chosen to Participate in an Accelerator Program

Group of people in a meeting
Photo by Austin Distel on Unsplash
With over two decades of experience in the fields of plant genomics and developmental biology, Dr. Thomas Brutnell serves as the vice president of Gateway Biotechnology in St. Louis, Missouri. In this role, Dr. Thomas Brutnell oversees the product development of repurposed FDA-approved drugs and new drug candidates to prevent and treat noise-induced hearing loss.

Gateway Biotechnology was chosen to join the MassChallenge Boston, a zero-equity, competition-based accelerator program that offers an opportunity for startups to win more than $1 million in cash prizes. 

Founded in Boston, Massachusetts, in 2009, MassChallenge supports startups with the highest potential to make a positive impact across all industries worldwide. In March 2019, MassChallenge chose more than 100 startups with focuses ranging from health care and life sciences to high tech, consumer goods, cleantech, and social impact to participate in the accelerator program.

In addition to winning cash prizes, startups will also gain access to expert mentorship, networking with corporate partners, and spacious co-working spaces at the Innovation and Design Building in Boston. During the program, the participants will partake in an evidence-based curriculum that tackles the essential stages of product development.